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Postdoctoral Fellow in Regulation of protein liquid droplets during transcription

Výzkumná pozice | Inzerováno od 25.09.2024 |

 Come to CEITEC MU in Brno and join us!

We are passionate structural biologists at CEITEC looking for 

        Postdoctoral Fellow in Regulation of protein liquid droplets during transcription

About this position: 

We're excited to announce an open post-doctoral position in Robert Vacha's Research Group!

Cells employ protein liquid droplets to form dynamic clusters, which function as nanoreactors or storages with the increased local concentration of specific protein components. These membrane-less organelles self-assemble based on weak protein-protein interactions of intrinsically disordered domains. However, the role of specific sequences remains elusive and the mixing between different protein droplets unexplored.

This ERC-funded project aims to the droplets involved in genome transcription, where posttranslational modifications control the droplet composition and regulate the transcription. Expected findings are not only important for the general knowledge but could also be useful in the design of new treatments because translocation malfunction is involved in numerous diseases including cancer. The research is strongly coupled to collaborations with excellent experimental teams and will be more closely discussed during the interview. The employed tools will contain multi-scale simulations using a wide range of advanced sampling techniques and development of protein parametrization.

The ideal candidate profile: 

Must-have: 

• PhD in computational simulations and related fields
• Theoretical knowledge of Molecular Dynamics and free energy calculations
• Some years of work experience in simulations with proteins/membranes and their analysis
• Published in impactful journals in the field, corresponding to given stage of career demonstrating creativity and scientific quality
• Good English language – spoken and written

Nice-to-have:   

• Good communication and interpersonal skills
• Motivation and a collaborative mindset

What we provide to you: 

• Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff
• Full-time contract
• An attractive salary (ERC funded position)
• Flexible working hours
• Support for further education and professional development 
• Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons directly at the campus 
• Kindergarten Elánek in Campus
• Support in these areas:
  • Welcome Office service before and after arrival 
  • Grant Office support 
  • Postdoc Peer Committee  
  • CEITEC events – workshops, conferences, lectures, training, family gathering etc. 

How to apply? 

Application deadline: 31.12.2024

Start date: 1.1.2025 or by negotiation

Applications, including a CV, motivation letter, list of publications, and contacts for at least two references should be sent an e-application. 

Any troubles with the e-application, please contact Petra Linhartova (petra.linhartova@ceitec.muni.cz)